The Somatomedin Hypothesis: 2001
نویسندگان
چکیده
منابع مشابه
The somatomedin hypothesis: 2001.
Since the original somatomedin hypothesis was conceived, a number of important discoveries have allowed investigators to modify the concept. Originally somatic growth was thought to be controlled by pituitary GH and mediated by circulating insulin-like growth factor-I (IGF-I, somatomedin C) expressed exclusively by the liver. With the discovery that IGF-I is produced by most, if not all, tissue...
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Somatomedin is a polypeptide(s) which "mediates" the actions of growth hormone. This pituitary dependent hormone was previously called "sulfation factor," a term derived from the bioassay technique which measures the incorporation of radioactive sulfate into cartilage glycosaminoglycans. Somatomedin has a more general effect upon cartilage; it is necessary for the cell multiplication and cartil...
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Serum somatomedin activity of rats was measured under several dietary conditions by 35S incorporation into chick embryo pelvic rudiment. The mean (+/- SD) serum somatomedin activity (U/ml) was reduced following 3 days of fasting (0.41 +/- 0.12) and increased to prefasting levels in animals fed a balanced diet (0.95 +/- 0.11) for 2 days. The increase in mean somatomedin activity following 2 day...
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Abnormalities of synovial fluid, as a lubricant and nutrient, may have relevance to the causation of certain articular diseases. The somatomedin activity in normal synovial fluid obtained from the knee joint of the ox has been studied and compared with the activity in serum from the same animal. The porcine costal cartilage bioassay of Van den Brande and Du Caju (1974) has been used with the is...
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Primary somatomedin deficiency: case report. A child presenting with the clinical features of hyposomatotropism but with high immunoreactive plasma growth hormone is described. During short-term administration of human growth hormone (HGH) his response with regard to fasting blood-glucose and free fatty acids, plasma-somatomedin, urinary excretion of calcium, nitrogen, and hydroxyproline was mi...
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ژورنال
عنوان ژورنال: Endocrine Reviews
سال: 2001
ISSN: 0163-769X
DOI: 10.1210/er.22.1.53